{"id":674,"date":"2019-01-11T02:35:08","date_gmt":"2019-01-11T02:35:08","guid":{"rendered":"http:\/\/protobiology.org\/wp3\/?p=674"},"modified":"2026-06-24T22:58:30","modified_gmt":"2026-06-24T22:58:30","slug":"studying-natural-biology","status":"publish","type":"post","link":"http:\/\/protobiology.org\/wp3\/2019\/01\/11\/studying-natural-biology\/","title":{"rendered":"Studying natural biology"},"content":{"rendered":"<p><a class=\"bookmark\" name=\"biology\"><\/a><\/p>\n<h1>Studying natural biology<\/h1>\n<p>We use synthetic cells to reconstitute and study natural biological processes, and to prototype and validate bioengineering tools that can be later used in live natural cells.<\/p>\n<h2>Engineering generalized RNA-protein interactions: a toolbox for regulation and readout of gene expression<\/h2>\n<p>We developed and validated protein architecture which binds to single stranded RNA. Using this protein technology, we are developing tools for visualization and quantification of levels of expression of genes of interest. This tool will work by following the reconstitution of a protein probe upon interaction of sequence-specific RNA binding proteins with the mRNA of the gene of interest.<\/p>\n<p>We are also aiming to edit the transcriptome of the gene of interest, selectively decreasing the level of expression of one splice variant (as opposed to cutting the DNA of the gene, which targets all splice variants indiscriminately).\u00a0<br \/>\nThis technology could potentially help in studying non-ER translation events, elucidating mechanisms of synaptic plasticity, as well as studying healthy and diseased translational profiles of genes, e.g., those involved in oncogenesis and other disease processes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Studying natural biology We use synthetic cells to reconstitute and study natural biological processes, and to prototype and validate bioengineering tools that can be later used in live natural cells. Engineering generalized RNA-protein interactions: a toolbox for regulation and readout of gene expression We developed and validated protein architecture which binds to single stranded RNA. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"http:\/\/protobiology.org\/wp3\/2019\/01\/11\/studying-natural-biology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Studying natural biology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-674","post","type-post","status-publish","format-standard","hentry","category-static"],"_links":{"self":[{"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/posts\/674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/comments?post=674"}],"version-history":[{"count":10,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/posts\/674\/revisions"}],"predecessor-version":[{"id":2227,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/posts\/674\/revisions\/2227"}],"wp:attachment":[{"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/media?parent=674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/categories?post=674"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/protobiology.org\/wp3\/wp-json\/wp\/v2\/tags?post=674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}