Mirror life is a scientific fantasy leading to a dangerous reality
https://theconversation.com/mirror-life-is-a-scientific-fantasy-leading-to-a-dangerous-reality-a-synthetic-biologist-explains-how-mirror-bacteria-could-conquer-life-on-earth-245842
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A roadmap towards the synthesis of Life; |
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Quencher-Free Fluorescence Monitoring of G-Quadruplex Folding; |
Mirror Bacteria Research Poses Significant Risks, Dozens of Scientists Warn
https://www.the-scientist.com/mirror-bacteria-research-poses-significant-risks-dozens-of-scientists-warn-72419
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Confronting risks of mirror life; |
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Technical Report on Mirror Bacteria: Feasibility and Risks; |
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Engineering Biology for Space Health: An Innovative Research Roadmap; |
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Laws of thought in living cells; |
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Alternate conformational trajectories in ribosome translocation; |
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preprint Nonenzymatic, prebiotic aminoacylation couples chirality of RNA and protein; |
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Emergent ribozyme behaviors in oxychlorine brines indicate a unique niche for molecular evolution on Mars; |
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Sequential gentle hydration increases encapsulation in model protocells; |
Scientists disagree on the origin of life
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PACRAT: Pathogen detection with aptamer-detected cascaded recombinase polymerase amplification-in vitro transcription; |
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Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities; |
Discussion on the origin(s) of life with Kate Adamala, Addy Pross and Chrisantha Fernando
Quanta Magazine podcast, "Even Synthetic Life Forms With a Tiny Genome Can Evolve".
By watching “minimal” cells regain the fitness they lost, researchers are testing whether a genome can be too simple to evolve.
https://podcasts.apple.com/us/podcast/even-synthetic-life-forms-with-a-tiny-genome-can-evolve/id1021340531?i=1000641216723/
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preprint Quencher-free fluorescence monitoring of G-Quadruplex folding; |
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Preparing for the Future of Precision Medicine: Synthetic Cell Drug Regulation; |
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Controlled exchange of protein and nucleic acid signals from and between synthetic minimal cells; |
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Cell-Free Expressed Membraneless Organelles Inhibit Translation in Synthetic Cells; |
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preprint High yield, low magnesium flexizyme reactions in a water-ice eutectic phase; |
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Present and future of synthetic cell development; |
Kate talked about engineering cells from scratch for biotechnology applications.
the-scientist.com/podcasts/the-art-and-science-of-synthetic-biology-71525
podbean link: thescientistspeaks.podbean.com/e/the-art-and-science-of-synthetic-biology
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Trumpet is an operating system for simple and robust cell-free biocomputing; |
Kate talked about engineering synthetic cells as part of SynBYSS seminar series. Recording on youtube.
Excellent summary of work on the evolution of minimal living cells.
Congratulations to Berenice Guerra and Hailee Aro for presenting their posters at the Summer Undergraduate Research Expo.
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Encyclopedia of Astrobiology; |
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Cell-Free Expression System Derived from a Near-Minimal Synthetic Bacterium; |
Congratulations to Evan Kalb and Abbey Robinson for winning poster prizes at SynCell2023.
Kate and Judee talk about Trumpet biocomputing platform and practical applications for medicine.
Our Trumpet platform summarized with emphasis on biomedical applications.
Congratulations to Emma Gehlbach for presenting her poster at the Undergraduate Research Symposium.
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A gene expression control technology for cell-free systems and synthetic cells via targeted gene silencing and transfection; |
Kate talked about building life in the lab on the Reason with Science channel. Recording on youtube or podcast website.
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New Aequorea fluorescent proteins for cell‐free bioengineering; |
Kate participated in the AAAS panel announcement of the new Origins Initiative.
https://www.phy.cam.ac.uk/news/humanitys-quest-discover-origins-life-universe
Kate participated in space exploration panel at the Swiss Embassy in DC, hosted by His Excellency Embassador Pitteloud.
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Parasites, infections and inoculation in synthetic minimal cells; |
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T7Max transcription system |
Kate was guest of the Neha Anwar podcast, talking about biomedical and other practical applications of synthetic cell engineering.
Synthetic cell engineering podcast.
Kate was guest of the YoloTalks podcast, talking about artificial cells and space exploration. Youtube: Creating artificial cells, and Spotify version.
Our lab was featured in CBS Connect article "Life as we don't know it".
Kate participates in webinar "Building a Synthetic Biology Platform for Drug Delivery" organized by The Scientist.
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A ubiquitous amino acid source for prokaryotic and eukaryotic cell-free transcription-translation systems |
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Engineering Ribosomes to Alleviate Abiotic Stress in Plants; |
The first student graduated from our lab. Congratulations, Dr. Gaut!
https://www.statnews.com/2022/07/26/fda-develop-framework-evaluate-synthetic-cells/
Evan presented a poster, and Orion and Kate did a liposome demo at SynCell 2022. 
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Expanding luciferase reporter systems for cell-free protein expression; |
Kate Adamala wants to make life from scratch! As Professor at University of Minnesota working on the origins of life and building a synthetic cell, Kate’s work touches on astrobiology, synthetic cell engineering, and biocomputing. Kate and her team create tiny bioreactors. These have applications in synthetic biology, drug development and biosensing. Building Artificial Cells with Kate Adamala | Late Night Conference with Wilhelm Huck 2x05.
Kate gave talk at the Fargo Theater on engineering synthetic life.
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Traditional protocols and optimization methods lead to absent expression in mycoplasma cell-free gene expression platform |
Synthetic biology allows us to build minimal cell-like systems, to investigate origin of life and build tools for space exploration.
The life of our Last Universal Common Ancestor | LAS 2021.
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Akaby - cell-free protein expression system for linear templates |
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Diffusion control in biochemical specificity; |
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Switchable DNA-based Peroxidases Controlled by a Chaotropic Ion; |
Abbey, Anders and Orion presented posters at Build-a-Cell Workshop 8 at Caltech.
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Making Security Viral: Shifting Engineering Biology Culture and Publishing; |
Akaby strain for linear TxTl is now available to all non-profit users: Akaby strain and information
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Liposome Preparation by 3D-Printed Microcapillary-Based Apparatus; |
Advanced Science News piece:
Artificial cells with specialized internal chemistries could revolutionize how we approach precision medicine.
https://www.advancedsciencenews.com/artificial-cells-valuable-niche-in-medicine/
Kate participates in The Dissenter webinar "Synthetic Cells, Cell Evolution, the Origin of Life, and Astrobiology".
Build-a-Cell video: Engineering synthetic cells for medicine
Kate was a guest of EBRC In Translation podcast, discussing science, safety and security of synthetic cell engineering ebrcintranslation.buzzsprout.com/1581817/9465178-9-building-cells-and-synbio-in-space-w-kate-adamala
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Build-a-Cell: Engineering a Synthetic Cell Community |
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Synthetic Cells in Biomedical Applications |
Our simple, 3D printed liposome formation device is now available to all non-profit users: device, protocols and tutorials
CRS News published our text about synthetic cells in drug delivery applications.
Synthetic cells: happy middle between liposome drug delivery and engineered natural cells
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Building a community to engineer synthetic cells and organelles from the bottom-up |
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Toward synthetic life: Biomimetic synthetic cell communication |
TRUMPET: Transcriptional RNA Universal Multi-Purpose GatE PlaTform is our new biocomputing tool. The web based logic gate design tool is now live on trumpet.bio
Kate's iBiology talks on synthetic cells have been published.
Part 1: Synthetic Cells: Building Life to Understand It
Part 2: Synthetic Cells: Approach and Applications
Kate participates in webinar Synthetic Cells · Artificial Life · Brain-Computer Interfaces · Space Exploration hosted by the Molecular Programming Interest Group.
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Reconstituting Natural Cell Elements in Synthetic Cells |
Kate participated in the Santa Fe Institute workshop Origins of Life: the Possible and the Actual.
2021-01-22 19:00:10
Webinars of the Origins Center, the Netherlands: "Life but not alive"
Life but not alive.
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Spatial multiplexing of fluorescent reporters for dynamic imaging of signal transduction networks |
Kate was a guest of Space Explr podcast, discussing Science And Engineering of Building Synthetic Cells https://www.youtube.com/watch?v=4fznl9wLtmw
2020-12-05 23:20:31
Kate was guest speaker at Darwin 2020, One of India's Biggest Evolutionary Movements in Biology
2020-11-25 05:20:14
Kate participated in Santa Fe Institute podcasts on the Andromeda Strain and Meaning of Life.
with Sara Walker:
https://www.youtube.com/watch?v=TH7O5IQpC1A
with Chris Kempes
https://www.youtube.com/watch?v=79qzllZrroc
2020-10-29 18:53:09
Kate Adamala and Trinity Hamilton from the College of Biological Sciences at the University of Minnesota discuss how tiny life forms on the fringes may illuminate huge truths about life in the universe. What do microbes that live on glaciers and in snow on Earth tell us about the potential for life on Mars? What can a cell made from scratch in a lab reveal about how life may have originated here on Earth—and beyond? This research on extremophiles and synthetic cells provides a unique take on life that may shed important insights into space travel and extraterrestrial life.
Probable Meets Possible: When Life Gets Weird.
Popular science podcast on extremes of life: Probable Meets Possible: When Life Gets Weird, by CBS and Bell Museum:
https://www.youtube.com/watch?v=82MmOBJK9B0
2020-09-22 20:48:17
Kate gave a seminar for the Community of Biotechnology.
https://www.facebook.com/cbiotechnology/videos/680207569301004/
2020-09-21 23:49:47
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Rapid deployment of smartphone‐based augmented reality tools for field and online education in structural biology |
Aanika Biosciences presents conversation series on topics of cutting edge synthetic biology.
Conversations with Aanika E10: Creating Synthetic Cells with Dr. Kate Adamala.
Short interview about synthetic cell engineering: https://www.youtube.com/watch?v=kDAPfVLkTts
2020-06-05 01:33:56
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Highly specific, multiplexed isothermal pathogen detection with fluorescent aptamer readout |
Kate helped with Quanta Magazine Bacterial Complexity Revises Ideas About ‘Which Came First?’ podcast.
https://www.quantamagazine.org/bacterial-organelles-revise-ideas-about-which-came-first-20190612/
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Toward artificial photosynthesis Nathaniel J Gaut and Katarzyna P Adamala Science Vol. 368, Issue 6491, pp. 587-588 journal link |
Opinion on lab operations in The Scientist
https://www.the-scientist.com/opinion-lab-work-under-isolation-67398
2020-04-08 18:49:26
Kate chaired the first session of the EBRC virtual annual meeting:
Cell-Free session.
2020-03-27 05:13:47
Kate gave seminar for the Center for Genome Engineering, in the new era of zoomeetings.
2020-03-05 05:42:47
Kate's Waterloo seminar is posted online. Primer on synthetic cell work in our lab and little bit of the overview of the field.
2020-02-07 05:03:55
Kate gave a seminar at the Waterloo Institute of Complexity and Innovation.
2020-01-31 05:01:50
Theodore, Orion, Kaitlin, Wakana and Kate went to Build-a-Cell Workshop #6 at NASA Ames.
2020-01-24 04:58:24
Kate is at Breakthrough Foundation Panspermia Workshop at the ASU Beyond Center for Fundamental Concepts in Science.
2019-12-04 01:08:00
Kate, Judee and Lauren are at Cell-Free Systems Conference in Boston.
2019-11-21 02:17:36
Kate's episode on P3 Dystopia show is now live.
https://sverigesradio.se/artikel/7345117
2019-11-20 01:03:27
Kate was visiting Department of Genetics, Cell Biology and Development at the Iowa State University.
https://www.gdcb.iastate.edu/gdcb-seminar-%E2%80%94-bioengineering-synthetic-cells
2019-11-18 05:16:06
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Connectome of synthetic cells: Comment on “What would a synthetic connectome look like?” by Ithai Rabinowitch; |
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Enabling community-based metrology for wood-degrading fungi; |
Kate participated in 2019 iGem Jamboree as a judge and as an adviser to the amazing Brown - Stanford - Princeton iGem team, supporting the Astropharmacy project.
https://2019.igem.org/Team:BrownStanfordPrinctn/Team
Kate represented Build-a-Cell community at the SynCell EU meeting in Madrid.
2019-10-16 01:32:19
Kate represented Build-a-Cell at the NSTC Interagency Synthetic Biology Workshop
https://ebrc.org/nstc-interagency-synthetic-biology-workshop/
2019-10-06 00:59:01
Kate represented Build-a-Cell community at the EBRC Global Forum For Engineering Biology: Initial Review Of Synthetic Biology National Strategies
https://ebrc.org/https-ebrc-org-global-forum-for-engineering-biology/
2019-08-29 19:20:47
We published interactive spreadsheet for liposome math: volyume, size, encapsulation rate and liposome numbers.
Kate, Judee and Wakana participated in Build-a-Cell Workshop #6 in Boston.
http://buildacell.io/engineering/workshop5/
2019-08-09 01:43:44
Kate gave talk at DNA25 in Seattle.
http://misl.cs.washington.edu/events/dna25/
2019-08-05 18:55:29
ComplexityExplorer.org course 'Origins of Life
Origins of Life: Chemical Comminalties - Early Metabolisms - An Introduction by Kate Adamala.
Kate gave talk at the Designer Biology: From proteins and cells to scaffolds & materials; in Newcastle UK
http://designer-biology.org/
2019-07-30 02:10:49
Kate's episode on Sean Carroll's Mindscape podcast is live.
https://www.preposterousuniverse.com/podcast/2019/07/22/56-kate-adamala-on-creating-synthetic-life/
2019-07-25 01:45:17
Kate gave talk at the Society for Molecular Biology and Evolution annual meeting in Manchester, UK
2019-07-19 18:09:40
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Biology on sample size of more than one |
Interview with Kate about Build-a-Cell
2019-06-28 02:26:25
Kate participated in origin of life panel at the Interplanetary Festival in Santa Fe.
https://interplanetaryfest.org/
2019-06-25 02:21:57
Kate organized Build-a-Cell session at SEED 2019.
2019-05-29 18:46:20
Breakthrough Discuss 2019 was held at UC Berkeley April 11-12, 2019. The theme, “Migration of Life in the Universe,” brought together an all-star group of astronomers, biologists, chemists and other experts to discuss whether and how primitive life can move between planets and stars, and if that is how life began on Earth.
Kate Adamala | Life, But Not Alive: Breakthrough Discuss 2019 .
Kate participated in OoLALA seminar series, talking about minimal life.
Kate gave seminar at Foundations Of Nanoscience: Self-Assembled Architectures And Devices (Fnano19).
Kate, Aaron, Joe, Tanner, Judee and Wakana participated in 2019 Breakthrough Discuss meeting.
Kate, Nathan and Chris participated in Build-a-Cell Workshop #4.
Our lab is proud to be a part of new Templeton Foundation team to study chemical emergence of life.
Exploring the informational transitions bridging simple chemistry and minimal life
Kate presents at the kick-off meeting for the SemiSynBio project, talking about biocomputing using synthetic cells.
Great editorial in Science intorducing new, exciting paper and highlighting interesting aspects of building synthetic cells.
Kate participated in the ASU-SFI Theory in Origins of Life Working Group in Phoenix.
Nathan, Lauren, Joe, Matt and Adam brough in vitro transcription demo to science fair at Andersen United Community School.
Excellen editorial in Nature, describing rationale of engineering synthetic life, and the most common approaches to various problems we're facing en route to a ynthetic cell. 
Local copy pdf
Kate went to Santa Fe Institute Workshop "Major Transitions in Life: Origins to Translations", a kick-off meeting for Exploring life's origins project at Santa Fe Institute.
Kate presented at Synthetic Biology for Defense Workshop in Arlington, Virginia.
Congratulations for Jose Alejo, he was named this year's Hanna H. Gray Fellow by the Howard Hughes Medical Institute.
Hanna Gray Fellows
Kate presented at 1st International Symposium on Building a Synthetic Cell , amazing meeting dedicated to construction of synthetic cells.
We hosted Build-a-Cell Workshop #3 in Minneapolis.
Amazing group of people discussing ways to make life.
Kate presented at Annual Conference of the Genome Writers Guild
Our lab is part of a new project to support large scale developement of biocomputing technologies, jointly funded by the National Science Foundation (NSF) and the Semiconductor Research Corporation (SRC).
Our synthetic cell experiment launched today at NASA Wallops!
The take off was luckily uneventfull, we're excited to start analyzing data now.
Congratulations to Nathan Gaut for winning second place in the UMn 3MT finals!
Kate attended NSF Synthetic and Artificial Cells Workshop in Alexandria VA.
Kate gave talk on bioengineering with synthetic cell at 3rd Synthetic Biology USA Congress
Kate and Brock were attending Build-a-Cell #2 Workshop, hosted at Stanford.
buildacell.io
Kate participated in What is life conversation about origins and earliest evolution of life , led by Carl Zimmer at Caveat in New York City.
Kate talked and run a workshop at 2017 Envision meeting at Princeton.
Kate is judging 2017 iGem during 2017 Giant Jamboree in Boston.
Kate talked about synthetic cell technologies for biomimicry at Nature-Inspired Exploration for Aerospace Summit at Ohio Aerospace Institute.
Kate visited Abbvie to talk about using synthetic cells for cell-mediate therapy.
Kate was a speaker at EON Workshop on Universal Biology at ELSI in Tokyo.
Kate was a speaker at Fab13 Symposium during Fab13 meeting in Santiago, Chile.
2017-07-30 02:20:28
Interesting summary of the origins of Build-a-Cell initiative.
Kate gave a talk, and various lab members had names on few posters during XVIIIth International Conference on the Origin of Life
Kate published commentary on using synthetic cells to prototype cell circuits in Cell Systems journal.
Kate's Medium post Why should we personalize medicine?
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What Is the Role of Circuit Design in the Advancement of Synthetic Biology? |
Kate is giving a talk, and Nathan is presenting a poster at SB7, The Seventh International Meeting on Synthetic Biology in Singapore.
Kate and Aaron are visiting Ting Zhu at Tsinghua University in Beijing.
Welcome Brock Cash to the lab!
Aaron and Kate did NPR podcast on the origin of life - Brains on!
Kate gave a talk, while Joe and Nathan presented posters at Grand Challenges Vision Symposium Innovations in Biology - Advancing Biomanufacturing
Jose Gomez-Garcia won 2nd place poster presentation prize at CBS Postdoc Symposium.
Welcome Kei Takahashi to the lab!
Kate at Physics of Living Matter workshop at the Beyond Center, ASU.
Kate at UCSF, seminar, "Life but not alive: building a cell from scratch"
Reddit AMA on synthetic minimal cells, answering questions from the public about our work. AskScience AMA Synthetic Cells.
Kate presented concept of building synthetic minimal cells, with its biotechnological, biomedical and basic science implications, in a TEDx talk "Life but not alive".
Welcome Joe Heili to the lab!
Engineering genetic circuit interactions within and between synthetic minimal cells;
Katarzyna P. Adamala*, Daniel A. Martin-Alarcon*, Katriona R. Guthrie-Honea, Edward S. Boyden;
Nature Chemistry, 9, 431-439, 2017, doi:10.1038/nchem.2644; *equal contribution
publisher website link
local copy pdf
Our lab become affiliated with the Masonic Canter Center.
We're proud to become part of this amazing research community.
So we are working on building "simplified cells" now. Associated Press noticed (local copy pdf).
So did MPR news (local copy pdf).
Welcome Jose Gomez-Garcia to the lab!
Kate at BioHack the Planet!
Astrobiology Primer 2.0.;
Domagal-Goldman and Wright et al. (includes chapter editor K.P.Adamala)
Astrobiology, 2016, 16(8):561-653. doi:10.1089/ast.2015.1460
publisher website link
Our lab become member of the University of Minnesota RNA Supergroup.
How to grow almost Anything?
HTGAA Class is back in 2016. More students, more sites.
G Xu, E Boyden, KD Piatkevich, K Adamala
US Patent App. 15/099,232, 2016
outside link
ES Boyden, KP Adamala, DA Martin-Alarcon
US Patent App. 14/995,169
outside link
The theme of the 12th international Fab Lab conference in Shenzhen, China, is fab labs that make fab labs: systems that makes systems, applying the biology concept of self-replicating systems into the fabrication world.
Kate is giving a talk on synthetic life during the plenary Symposium.
What if we build life instead of growing?
Or what if we grow machines instead of building?
Programmable RNA-binding protein composed of repeats of a single modular unit;
Katarzyna P. Adamala*, Daniel A. Martin-Alarcon*, and Edward S. Boyden;
PNAS, 2016, 10.1073/pnas.1519368113; *equal contribution
local copy pdf
publisher website link
Kate speaks at TEDxEsteeLauderCompanies event at MoMA in New York City.
Collaboration between primitive cell membranes and soluble catalysts;
K. Adamala*, A. E. Engelhart* and J. W. Szostak;
Nature Communications, 2016, doi:10.1038/ncomms11041; *equal contribution
local copy pdf
publisher website link
The FabLab Lima and Konrad Adenauer Foundation organised workshop Floating FAB LAB Amazon.
We discussed the opportunities for using synthetic minimal cells as biosensors in the Floating FabLab on the Amazon river.
Introducing How To Grow (Almost) Anything
The first synth bio FabLab Academy includes Kate's unit on synthetic minimal cells.
Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension;
K. Adamala*, A. E. Engelhart* and J. W. Szostak;
J. Am. Chem. Soc., 2015, 137 (1), pp 483 - 489, DOI: 10.1021/ja511564d; *equal contribution
local copy pdf
publisher website link
Construction of a Liposome Dialyzer for preparation of high-value, small-volume liposome formulations;
K. Adamala*, A. E. Engelhart*, N. Kamat, L. Jin and J. W. Szostak;
Nature Protocols, 2015, 10(6), pp 927-938; *equal contribution
local copy pdf
publisher website link
Open questions in origin of life: experimental studies on the origin of nucleic acids and proteins with specific and functional sequences by a chemical synthetic biology approach;
Adamala K, Anella F, Wieczorek R, Stano P, Chiarabelli C, Luisi PL;
Comput Struct Biotechnol J. 2014;9:e201402004
local copy pdf
publisher website link
Non-enzymatic template-directed RNA synthesis inside model protocells;
K. Adamala and J.W. Szostak,
Science 342 (2013) 1098 - 1100;
local copy pdf
publisher website link
